Is Amberen a Good Choice for Menopause Relief? (5 min.)

• Print Article

Summary: Did you know that there may be more than 30, and potentially as many as 100, different symptoms of menopause? It’s no wonder this life stage can feel overwhelming — especially when symptoms might impact so many aspects of daily life, including sleep, mood, and overall well-being. But menopause doesn’t have to mean losing control of your life. Growing research suggests that thoughtful lifestyle choices and targeted nutritional support may help alleviate discomfort associated with common menopause concerns and promote healthy aging†. In this article, we review Amberen and explore evidence-based options that may support women through this important life stage.

At Cooper Complete, we regularly answer questions about supplements and their role in a healthy lifestyle, often beyond our product line. One recent question we received was about dietary supplements that may help reduce menopause symptoms and whether Amberen® Advanced Menopause Relief is a good choice.

Menopause Facts: What to Expect During the Transition

Menopause begins 12 months after a woman’s last period. The years leading up to that point, when periods become irregular and hot flashes and other symptoms may occur, are called perimenopause, or the menopausal transition.

Perimenopause typically begins between the ages of 45 and 55 and normally lasts around 7 years, although it can continue for up to 14 years. During this time period, estrogen and progesterone levels fluctuate significantly, bones become less dense, and many women notice it becomes easier to gain weight.

Most women aged 45-55 experience numerous transitions during this decade, often balancing the needs of both children and aging parents or other relatives. The term “sandwich generation” aptly describes this stage of life.

Amberen Review: What the Research Really Shows

A note on hormone therapy: While many women consider vitamins and dietary supplements for menopausal support, it’s important to understand that prescription hormone replacement therapy (HRT) remains the most effective, evidence-based treatment for moderate to severe menopausal symptoms. For women who are good candidates, HRT can significantly improve hot flashes, night sweats, sleep disruption, and other quality-of-life concerns. Dietary supplements and lifestyle strategies may play a supportive role for some women, especially those with mild symptoms or those who cannot or choose not to use HRT†. However, decisions about HRT should always be made in consultation with your physician or qualified health care provider, who can evaluate individual risks and benefits.

Amberen is marketed as a multi-symptom menopause supplement. It combines various vitamins, minerals, and amino acids intended to support hormone-related symptoms†.

What’s in Amberen? A Look at the Ingredients

According to the label, Amberen contains calcium, magnesium, zinc, synthetic vitamin E, the amino acid glycine (an amino acid derived from soy), monosodium L-glutamate (commonly known as MSG), and ammonium succinate.

Glycine is one of 20 different amino acids that help build proteins in the body. It’s found naturally in protein-rich foods like meat, fish, dairy and legumes. In mouse models, glycine has shown estrogen-like effects on bone health, suggesting potential benefits for menopause symptoms†.

Each two-capsule serving of Amberen Menopause contains 400 mg of the components listed above, as a proprietary blend. While the exact amount of each ingredient in the blend isn’t disclosed (except for the vitamin E at 5.04 mg per serving), supplement labels are required to list ingredients in order of predominance by weight. That means the first ingredient, ammonium succinate, is present in the highest amount, while the last, zinc difumarate, is present in the smallest. The full ingredient order is:

• Ammonium succinate
• Calcium disuccinate
• Monosodium L-glutamate
• Glycine
• Magnesium disuccinate
• Zinc difumarate

Does Amberen Work? What the Studies Say

In 2019,  raw data from two identical randomized, placebo-controlled 90-day clinical trials were pooled and analyzed.  Each trial included 125 women (ages 42-60) with mild to moderate menopausal symptoms. Half of the women took Amberen for 90 days, while the other half received a placebo. Researchers found that Amberen provided relief from mild to moderate climacteric symptoms†.

Of note, the four authors of this study all have disclosed conflicts of interest. One is a paid consultant for Amberen, and the other three were involved in the original studies being reviewed.

It’s important to keep in mind that prescription hormone replacement therapy (HRT) is the most effective approach for managing menopausal symptoms. If HRT medications are contraindicated due to other health issues, consult your physician or health care provider about alternative options.

Natural Supplements That May Support Menopause Symptoms†

The ingredients found in Amberen are also found in many other foods and nutritional supplements. Making healthy dietary and lifestyle choices can offer many benefits and support the body during the aging process†.

Melatonin for Occasional Sleeplessness During Menopause†

Sleep disruptions are common during menopause. A lack of sleep can increase stress, anxiety, and irritability. A study by the National Institutes of Health (NIH) found that sleeping less than seven hours per night increases the risk of obesity by 30 percent.

We recommend melatonin for occasional sleeplessness†. Melatonin helps regulate the body’s natural sleep cycle† and is a non-habit-forming alternative to prescription sleep aids. Natural melatonin levels tend to decrease with age. Melatonin supplements are available in both quick-release and prolonged-release formulations, as well as a low-dose formulation.

[Bonus: Review habits for better sleep†.]

Vitamin D and Omega-3 for Energy, Mood and Active Living†

Many women experience fatigue and a slower metabolism during menopause. While it may seem counterintuitive, regular exercise can improve mood, reduce stress, and support overall health. Just 30 minutes of exercise per day can make a difference.

The Cooper Complete Healthy Body Pack is designed to help meet the nutritional needs of active adults. It includes:

• Omega-3 fatty acids, linked to heart health and mood support†
• Magnesium, which supports energy production and sleep†
• A multivitamin with a total of 15 essential vitamins and minerals, including vitamin D, which plays a role in mood† and immunity†

Compared to Amberen, which includes three vitamins and minerals, our multivitamin offers a broader nutrient profile.

Trusted Sources for Menopause Information

If you think you may be entering menopause, first and foremost, talk with your physician or health care provider about your symptoms and possible options.

As a consumer, seek out reputable and scientifically backed facts on menopause. Reliable resources are available online through multiple government agencies, as well as through reputable universities and major medical institutions. Below are a few of the publications:

• Top Questions About Menopause – Information from the Office On Women’s Health (U.S. Department of Health & Human Services)
• Get the Facts: Menopausal Symptoms and Complementary Health Practices– National Center for Complementary and Alternative Medicine at the National Institutes of Health
• What is menopause? – National Institute on Aging
• Menopause fact sheets– U.S. Food and Drug Administration (FDA)

When considering supplements, look for products supported by science, and always review the ingredient panel. Supplements can play a helpful role in a healthy lifestyle. As Dr. Kenneth H. Cooper recommends in his 8 Steps to Get Cooperized™, taking the right supplements for your individual needs can make a difference.

Shop Supplements for Women

Take The Quiz

About the Author: Jill Turner is the President of Cooper Complete® Nutritional Supplements, where she oversees product development and customer experience. She enjoys writing about vitamins, supplements, and preventive health to help consumers make informed, science-backed decisions.

Cooper Complete January 13, 2026