Best Supplements for PCOS Support†: What the Research Says (7 min.)

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Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting 6-12% of women in the United States, ages 15-44. Caused by an imbalance of reproductive hormones, this disorder can lead to the development of cysts in the ovaries and may contribute to symptoms that affect reproductive health†. While there is no cure for PCOS, practicing healthy lifestyle choices, including proper sleep, exercise and consuming adequate nutrients through a healthy diet and supplementation†, can help reduce symptoms†.

Causes and Symptoms of Polycystic Ovary Syndrome (PCOS)

The name polycystic ovary syndrome describes the small cysts—fluid-filled sacs—that form in the ovaries. However, the presence of cysts isn’t always related to PCOS. Some women with PCOS may not develop cysts, while others without PCOS may develop them. PCOS can affect women of all races and ethnicities, but several factors may increase the chance of developing this disorder, including:

• Obesity
• Waist circumference greater than 35 inches
• Family history of PCOS (mother, sister, or aunt)
• Elevated androgen (“male hormones”) levels
• High insulin levels or insulin resistance
• Chronic, low-grade inflammation

Confirmation of two or more of these symptoms—irregular periods or no period at all, higher than normal levels of androgens or multiple small cysts on the ovaries—results in a medical diagnosis of PCOS. However, not all women who have PCOS will show all symptoms; in fact, some women will have no symptoms at all. In some cases, cysts can rupture and resolve on their own, but in rare instances, laparoscopic surgery is necessary to remove the cyst.

To be diagnosed with PCOS, your health care provider will discuss your medical history, including your genetics, and possible symptoms, which may include:

• Irregular menstrual cycle
• Hirsutism (too much hair)
• Acne
• Thinning hair on the scalp
• Weight gain (and/or difficulty losing weight)
• Darkening of skin
• Skin tags

Due to the symptoms of PCOS mimicking other health concerns, your physician may perform additional tests to confirm your diagnosis. An ultrasound can be used to capture images of the blood vessels, tissues, and organs, as well as to assess the size of the ovaries and detect the presence of cysts. Blood tests can be used to determine androgen and hormone levels, as well as blood glucose, cholesterol, and triglyceride levels.

PCOS increases the risk of other serious health issues, including diabetes, gestational diabetes, heart disease, high blood pressure, elevated LDL (“bad”) cholesterol, sleep apnea, stroke, depression, anxiety and endometrial hyperplasia. Symptoms and other potential health risks of PCOS can affect daily life, but developing healthy lifestyle practices, including maintaining a healthy weight and engaging in regular exercise, can help relieve symptoms.

Best Supplements for PCOS Support†

Although no supplements are formulated to treat or cure PCOS, some may support aspects of health that are commonly affected in those with PCOS†.

Berberine, Turmeric and Zinc for PCOS Support†

Many women with PCOS have insulin resistance—a condition where the body’s cells do not respond normally to insulin. Insulin resistance is especially common in those who are overweight, have unhealthy eating habits, do not get enough physical activity and those with a family history of diabetes. Over time, insulin resistance can lead to type 2 diabetes. Berberine, turmeric and zinc may support healthy insulin function†.

Research shows berberine can help manage diabetes†, high cholesterol levels† and high blood pressure†. But berberine can also help support healthy blood sugar metabolism† and help maintain normal testosterone levels†. A 2020 study of berberine used as a supplement for women with PCOS showed an increase in fertility† and live birth rates†. The alpha lipoic acid and vitamin C found in Cooper Complete Berberine Complex support healthy glucose metabolism†, immune balance† and lower cholesterol†.

Many women with PCOS experience inflammation. Turmeric supplements contain curcumin, a compound with antioxidant properties that may support a healthy inflammatory response†. A 2021 clinical trial found that turmeric may help promote normal insulin sensitivity† and a healthy inflammatory response† in women with PCOS†. Cooper Complete Turmeric Curcumin supports joint health† and inflammation† with 1000 mg curcumin extract, a natural anti-inflammatory†.

Zinc is an essential nutrient for regulating cell growth†, hormone release†, immunological response† and reproduction†. In a review of 36 reproductive health studies, it was found that women with PCOS who supplemented with zinc experienced a positive effect on insulin resistance† and lipid balance†. Additionally, 20-30 mg of zinc supplementation, taken in one to four daily doses before and during women’s menstrual cycles, resulted in a reduced amount of menstrual pain†. Cooper Complete Zinc supplement contains 25 mg of zinc gluconate and zinc citrate.

Vitamin B12 Supplementation for PCOS†

Many women take metformin—a medication used to treat type 2 diabetes—and 6-30% of patients taking metformin have developed a vitamin B12 deficiency†. B12 aids in cell metabolism†, nerve function† and DNA production†. A deficiency in B12 may lead to tiredness or weakness throughout the day. Taking vitamin B12 can restore normal energy levels† and reduce overall tiredness† while also aiding in mood regulation† and offsetting the effects of metformin. Other B-complex vitamins may also help manage homocysteine levels that may be elevated due to PCOS.

Cooper Complete Vitamin B12 Methylcobalamin contains the most active, absorbable form of vitamin B12†.

Vitamin D Deficiency and PCOS†

Many women (67-85%) suffering from PCOS also develop a vitamin D deficiency. A nutrient we receive from ultraviolet rays (UV) and naturally occurring in small amounts in some fish (including tuna and salmon), and in fortified dairy, juices and many other items, and a hormone our bodies make, vitamin D plays an important role in supporting bone†, immune† and heart health†. Having a vitamin D deficiency in addition to PCOS could result in a higher risk of ovulatory dysfunction and metabolic syndrome. Taking 50 mcg (2000 IU) of vitamin D daily (found in all Cooper Complete multivitamins and standalone supplements) may help support symptoms of PCOS†, including insulin resistance†, menstrual irregularities†, infertility† and the elevated risk of cardiovascular disease†.

Magnesium and Melatonin for Sleep and Hormone Support in PCOS†

When most people think of melatonin, they think of the hormone that promotes better sleep†. However, a study on supplementation and PCOS found that co-supplementation of melatonin and magnesium not only improves sleep quality but also significantly reduces insulin levels†, insulin resistance†, cholesterol†, and testosterone levels†. Only a few studies have been conducted on the effect of melatonin on PCOS symptoms; however, a growing body of research shows promising results†.

Cooper Complete Magnesium Glycinate is well-absorbed and helps support bone health†, energy production† and heart health†. Co-supplementation with Cooper Complete Melatonin can improve sleep† and reduce insulin resistance†.

[Bonus: Learn about how magnesium supports overall health†.]

How to Choose the Right Supplements for PCOS†

Managing PCOS is a long-term journey, and no single solution is right for everyone. While there is currently no cure, healthy lifestyle habits, such as regular exercise, balanced nutrition, quality sleep, and targeted supplementation†, can help support hormone balance†, metabolic health†, and overall well-being†. As research continues to evolve, so does our understanding of how certain vitamins and nutrients may benefit those with PCOS†. Always consult with your physician or health care provider before starting any new supplement to ensure it’s appropriate for your unique health needs.

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Cooper Complete July 7, 2025