Supplements for Mood Health (5 min.)

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The Mind-Heart-Body Connection

We all know how laughter and a good mood make us feel physically, just as we recognize the tension and discomfort that can accompany anger or sadness. These physical effects are more than just emotions—research supports a powerful connection between the mind, heart, and body.

According to the National Institutes of Health, research shows a connection between positive mental health and improved health. The American Heart Association echoes this in a scientific statement that highlights the link between psychological well-being and cardiovascular health. Both organizations have conducted research that has shown positive attributes, such as optimism and emotional balance, have been associated with healthier weight, lower blood pressure, and a reduced risk of heart disease†. On the other hand, chronic stress, sadness, anxiety, and anger can contribute to elevated cortisol levels, heart rate and blood pressure, all of which may negatively impact heart health, mental health and immune function†.

Support Mood with Lifestyle and Nutrition

The American Psychiatric Association has identified several behaviors to help promote emotional well-being and support mental health:

• Exercise regularly. Physical activity has been shown to help support mood† and reduce stress†.
• Eat a balanced diet. Nutrients from whole foods, the colors of the rainbow, help support brain function†.
• Prioritize sleep. Restful, uninterrupted sleep is vital for cognitive health† and emotional stability†.
• Maintain social connections. The U.S. Surgeon General’s health advisory highlights the therapeutic benefits that meaningful relationships and social connections offer.
• Practice mindfulness. Meditation, breathwork, yoga, and similar practices can help calm the body and reduce perceived stress†.

Alongside these healthy habits, certain dietary supplements may help fill nutrient gaps and support mood health†. The following are a few supplements for mood health available from Cooper Complete Nutritional Supplements†.

Ashwagandha: Adaptogenic Support for Stress and Mood†

Cultivated from the roots of small evergreen shrubs found in dry tropical and subtropical regions of the Middle East, India and Africa, ashwagandha is an adaptogenic herb traditionally used to support the body’s response to physical and emotional stress†. A 2021 review of seven studies found that ashwagandha supplementation was associated with reduced perceived stress† and anxiety levels†. It may also help reduce cortisol levels†, occasional sleeplessness† and fatigue† related to stress.

Cooper Complete Ashwagandha contains 300 mg of standardized ashwagandha root in each daily serving. Consult your physician about the long-term use of ashwagandha and its effect on the liver and thyroid, and if you have prostate cancer or are pregnant or breastfeeding, before adding this or other supplements for mood health† to your routine.

[Learn more about the health benefits of ashwagandha†.]

Omega-3 Fatty Acids: Brain and Emotional Wellness†

Omega-3 fatty acids are essential nutrients our body cannot produce, making it important to consume them in the diet and/or supplements†. The American Heart Association recommends eating at least two three-ounce servings of fish per week. Types of fatty fish containing omega-3 fatty acids include salmon, mackerel, sardines, herring, bluefin tuna and anchovies, as well as oysters and mussels.

While there are several types of omega-3 fatty acids, two of the most important are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). EPA plays a key role in our body’s ability to fight inflammation†, while DHA is important for our brain and nervous system†, making up approximately 9-12 percent of our brain’s total weight.

Several observational studies have established that people who eat fish rich in DHA and EPA report better mood health†. While it did not address the effects of omega-3 intake, one 2006 study found that those with lower blood levels of omega-3 were more likely to report mild or moderate symptoms of depression as well as a generally more negative outlook†.

There are also several studies on the effects of omega-3 supplementation on people with symptoms of depression†. One small, recent study supports the use of omega-3 fatty acids as an adjunct therapy along with antidepressants to help reduce the severity of the symptoms of depression.

[Learn more about the health benefits of omega-3 fatty acids†.]

Cooper Complete Advanced Omega-3 contains 1,400 mg of omega-3 fatty acids in each daily serving, including 720 mg EPA and 480 mg DHA. Naturally flavored mango Advanced Omega 3 Liquid supplement contains 1300 mg (1.3 g) EPA, 850 mg DHA, and 175 mg DPA (Docosapentaenoic Acid) omega-3 fatty acids in each teaspoon (5 mL) serving. Advanced Omega-3 Plant-Based Supplement has 225 mg EPA and 450 mg DHA in each vegan soft gel capsule. With their higher DHA levels, Liquid Omega-3 and Plant-Based Omega-3 are excellent supplements for mood health†.

Folate: B Vitamin Support for Mood and Neurotransmitters†

Folate—or folic acid—is a B vitamin (B9) that supports neurotransmitter synthesis† and is involved in the production of serotonin and dopamine, both of which influence mood†. Folate can be found in a wide range of foods, including meat, seafood, poultry, eggs, dairy products and grains, as well as spinach, asparagus, Brussels sprouts, white rice and black-eyed peas.

A review of several studies on folate and depressive disorders found evidence of folate deficiency’s association with anxiety and elevated risk of depression†. Individuals with folate deficiency may also have a decreased response to antidepressant treatment and a higher risk of worsening cognitive function†.

Cooper Complete Methyl Folate contains 5,000 mcg of a methylated form of folate (5-MTHF), a highly bioavailable form of folate to support mood†, brain† and heart health†.

[Learn more about the benefits of folate†.]

Magnesium: Calming Mineral for Emotional Balance†

It is estimated that about half of the U.S. population does not get enough magnesium in their diets. 300 bodily functions depend on magnesium†, including the regulation of mood-related neurotransmitters†. Maintaining adequate magnesium levels is important for maintaining emotional stability† and preventing mood disorders†.

Since the body does not produce magnesium, it is essential to include sufficient amounts of this mineral in the diet. If you don’t get enough magnesium through foods such as leafy greens, legumes, nuts, seeds, and whole grains in your diet, supplementation can be a safe and viable option†.

A meta-analysis of seven clinical trials found supplementing magnesium for mood health produced significant declines in depression scores among adults with depressive disorder, indicating magnesium supplementation may help alleviate symptoms of depression†.

Cooper Complete offers three magnesium supplements for mood health†:

• Cognitive Health Magnesium L-Threonate Capsules – Contain Magtein®, a highly absorbable form of magnesium that crosses the blood-brain barrier† and supports cognitive function† and mental clarity†.
• Cognitive Health Magnesium L-Threonate Powder – Combines Magtein® with magnesium glycerophosphate and magnesium acetyl taurinate for expanded nervous system support†.
• Magnesium Glycinate Capsules – A gentle† and highly bioavailable† form that promotes relaxation† and overall mood balance†.

The Bottom Line: Supplements for Mood Health†

Incorporating targeted supplements for mood health can complement lifestyle habits like sleep, exercise, and stress reduction†. While these nutrients help fill potential gaps in the diet, it’s essential to have a well-rounded approach that includes lifestyle, exercise, social connection, and mindfulness for lasting emotional well-being. Always talk with your physician or health care provider before starting any new supplement to ensure it aligns with your individual health needs.

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About the Author: Cathy Sides is the Director of Customer Relations for Cooper Complete® nutritional supplements. Since joining Cooper Aerobics in 2007, she has helped customers make informed decisions about supplements. Cathy also contributes blog content focused on vitamins, supplements, and healthy living.

Cooper Complete June 26, 2025