Supplements to Fight Fatigue† (6 min.)

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Fatigue is a condition that drives 10-20 percent of primary care visits. It’s more than just feeling sleepy or tired; it’s a lack of energy and motivation that isn’t relieved by rest alone. Fatigue may be a symptom of a more serious physical or mental condition that requires medical attention.

Causes of Fatigue

The list of causes for fatigue is long and spans both health- and lifestyle-related factors. Researchers are increasingly studying fatigue as a key symptom of long COVID. Some of the more common health-related causes of fatigue include:

• Metabolic conditions: anemia, diabetes, liver and kidney disease
• Infectious diseases: mononucleosis, influenza, hepatitis and malaria
• Cardiac and pulmonary conditions: asthma, chronic obstructive pulmonary disease (COPD), pneumonia and coronary artery disease
• Medications: antidepressants, antihistamines, steroids and blood pressure medications
• Vitamin deficiencies: iron, folic acid and vitamins B12 and D†

Fatigue may also result from mental health and lifestyle-related reasons, including:

• Stress and anxiety
• Eating disorders
• Poor diet
• Grief and bereavement
• Alcohol or drug use
• Lack of exercise
• Overtraining or too much physical activity

Finding Relief from Fatigue

Most adults need at least seven hours of sleep every night. Even with proper rest, many adults still struggle with persistent fatigue. In addition to addressing underlying physical or mental conditions, lifestyle changes may help:

• Get regular exercise
• Eat a balanced, nutrient-dense diet
• Limit alcohol intake or stop drinking
• Practice stress-reducing techniques like relaxation, meditation, or breathwork

Instead of relying on caffeine or stimulants, evaluate your diet to ensure you’re getting all the essential vitamins and nutrients your body needs to function well†. If dietary intake is inadequate, consider supplements to fight fatigue† as a way to help fill potential nutrient gaps†.

Iron: Oxygen Transport and Energy†

Iron supports immune health and function† and helps transport oxygen throughout the body†—a function critical for maintaining energy. Iron deficiency is one of the most common nutrient deficiencies worldwide, affecting 25 percent of the world’s population. The World Health Organization (WHO) has labeled it the most widespread deficiency globally.

A meta-study of 18 randomized controlled trials found that iron supplementation reduced fatigue in non-anemic, iron-deficient individuals†.

[Read more about iron here.]

Cooper Complete Iron Bisglycinate Supplement contains 29 mg of gentle, highly absorbable Ferrochel^® iron, a patented form of chelated iron specifically designed to support iron levels without the usual side effects of gastric upset or constipation†.

B Vitamins: Cellular Energy Support†

Vitamins B6, B9, and B12 play essential roles in energy metabolism† and red blood cell production†. Deficiencies can lead to anemia and associated symptoms of fatigue†. Multiple studies show that B vitamin supplementation helps reduce fatigue† and support muscular strength†.

B vitamins are among the most common supplements to fight fatigue† as they help convert food into useable energy† and support neurological health†.

Cooper Complete Advanced B Complex includes eight essential B vitamins in their most bioavailable forms to support cellular energy production† and immune†, cardiovascular† and neurological health†.

Vitamin C: Antioxidant and Iron Absorption Support†

Vitamin C supports the immune system† and acts as a powerful antioxidant†. It enhances iron absorption†, a key function in preventing fatigue caused by iron deficiency†.

Diseases that cause oxidative stress, such as COVID-19, may increase fatigue, and vitamin C’s antioxidant properties may help combat this sterss†.

Cooper Complete Natural Vitamin C contains 850 mg of vitamin C with citrus bioflavonoids for additional cellular protection†.

CoQ10: Cellular Energy Production†

Also an antioxidant, coenzyme Q10 (CoQ10) provides energy to cells† and supports the immune system†, and is believed to protect the neurons that connect the brain to the muscles†. A meta-analysis of 13 randomized controlled trials showed that CoQ10-only supplements were effective in reducing fatigue symptoms†.

That same analysis found the most effective supplementation was with CoQ10-only formulations, as opposed to CoQ10 compounds. A separate, double-blind clinical study found that ubiquinol, a highly absorbable form of CoQ10, improved oxidative stress†, mental focus†, and fatigue symptoms†.

Cooper Complete CoQ10 Ubiquinol is available in 50 mg or 100 mg formulations for daily support†.

Ashwagandha: Adaptogenic Stress Support†

Ashwagandha is an adaptogenic herb used to support the body’s response to stress†. Gaining popularity in recent years for its ability to reduce stress† and support better quality sleep†, ashwagandha contains a group of substances called withanolides, considered to have anti-inflammatory† and antioxidant effects†.

Fatigue often accompanies stress and anxiety, so ashwagandha is frequently suggested in supplements to fight fatigue†, particularly those focused on nervous system and adrenal health†.

A 12-week study in overweight and mildly obese adults found that ashwagandha supplementation significantly reduced self-reported fatigue†. Additional research is needed to validate and provide additional insights into these results.

Cooper Complete Ashwagandha contains 300 mg of ashwagandha root (as withania somnifera) in each single-capsule serving.

(Bonus: Learn more about the health benefits of ashwagandha supplements†.)

Vitamin D: Immune Health and Mood Support†

Vitamin D deficiency affects about 42% of U.S. adults. Several studies have shown a connection between low vitamin D levels and increased fatigue†.

In a randomized controlled trial involving otherwise health adults with vitamin D deficiencies, single-dose vitamin D supplementation produced significant improvements in symptoms of fatigue†.

Cooper Complete offers three Vitamin D3 supplement products, including 25 mcg (1,000 IU) and 125 mcg (5,000 IU) in softgel form and a liquid version with 25 mcg (1,000 IU) per drop†.

Melatonin: Support for Sleep-Related Fatigue†

Melatonin is a hormone that helps regulate the sleep-wake cycle†. It may help individuals whose fatigue is related to poor sleep quality†. Melatonin also supports immune health† and has anxiotidant properties†.

Cooper Complete offers three melatonin formulas:

• Quick Release Supplement (3 mg) – Helps you fall asleep faster†
• Prolonged Release Supplement (5 mg) – Helps you stay asleep longer†
• Low-Dose Melatonin (1 mg) – Easily scorable for customized dosing†

(Bonus: Learn more about the best supplements to support restful sleep†.)

Why Vitamins and Supplements Matter in Fighting Fatigue†

Vitamins and minerals play a critical role in energy metabolism†, brain function†, and oxygen regulation†. When deficiencies are present, fatigue is a common symptom†. Addressing these gaps with proper supplementation may help support overall energy and vitality†.

For individuals struggling with low energy, supplements to fight fatigue† can be a valuable part of a broader strategy that includes sleep, stress management, and nutriton†.

A review of clinical evidence suggests that vitamin supplementation may benefit individuals experiencing both mental† and physical fatigue†. Before adding new supplements to your daily regimen to address symptoms of fatigue†, consult your physician or health care provider. They understand your health profile best and can discuss which supplements are most suitable for you, taking into account any underlying medical conditions you may have†.

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Cooper Complete June 26, 2025